Description

Crotamine is a bioactive polypeptide toxin derived from the venom of the South American rattlesnake (Crotalus durissus terrificus). This compound is of significant interest in biochemical and pharmacological research due to its unique cell-penetrating and myotoxic properties. It serves as a critical tool for scientists in the fields of drug delivery, molecular biology, and toxin research, enabling advanced studies on membrane interactions and intracellular transport mechanisms.

Application

• Biomedical Research: Used as a model cell-penetrating peptide (CPP) to study mechanisms of cellular uptake and intracellular trafficking.
• Drug Delivery Vector Development: Investigated for its potential to transport therapeutic molecules (e.g., drugs, DNA, peptides) across cell membranes.
• Toxicology Studies: Serves as a reference standard in research on myotoxicity and the effects of snake venom components.
• Pharmaceutical Discovery: Aids in the design and evaluation of novel peptide-based therapeutics and diagnostic agents.
• Biochemical Reagent: Employed in laboratory assays to probe membrane structure and function.
• Antimicrobial Peptide Research: Studied for its inherent antimicrobial properties and structure-activity relationships.

Basic Information

Product Name	Crotamine
CAS No.	58740-15-1
Molecular Formula	C204H342N68O57S6
Molecular Weight	~4887.6 g/mol
Synonyms	Crotamine Toxin; Crotamine Peptide; Crotamin; Myotoxin from Crotalus durissus terrificus; Cell-Penetrating Peptide Crotamine; CAS 58740-15-1; Ctn
EINECS	Contact for details

Quality Control

Our Crotamine is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high biological activity. Each lot is characterized using advanced analytical techniques, including mass spectrometry (MS) and high-performance liquid chromatography (HPLC), to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, bioactivity, and endotoxin levels is provided with every shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized (freeze-dried) material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to minimize freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Endotoxin Level (LAL)	< 10 EU/mg
Biological Activity	Confirmed by cell-penetration assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.