Description

Anagrelide Hydrochloride is a potent and selective platelet-reducing agent, primarily used as a key active pharmaceutical ingredient (API). Its core value lies in its ability to specifically inhibit megakaryocyte maturation, making it critical for managing thrombocythemia. This compound is essential for pharmaceutical manufacturers and research institutions developing treatments for myeloproliferative disorders, particularly essential thrombocythemia. Consistent quality and reliable supply are paramount for ensuring the safety and efficacy of the final drug product.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for the treatment of essential thrombocythemia (ET) and other myeloproliferative neoplasms.
• Formulation Development: Used in R&D for developing various dosage forms, including capsules and tablets, to optimize bioavailability and patient compliance.
• Clinical Research: Serves as a reference standard and investigational material in clinical trials exploring new indications or combination therapies for blood disorders.
• Analytical Standard: Employed as a high-purity standard in quality control laboratories for HPLC, LC-MS, and other analytical methods to ensure product identity and potency.
• Biochemical Research: Used in pharmacological studies to investigate mechanisms of platelet production and megakaryocyte function.
• Generic Drug Manufacturing: A critical component for companies producing bioequivalent generic versions of anagrelide-based therapeutics.

Basic Information

Product Name	Anagrelide Hydrochloride
CAS No.	58579-51-4
Molecular Formula	C10H7Cl2N3O • HCl
Molecular Weight	292.55 g/mol
Synonyms	6,7-Dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one monohydrochloride; BL-4162A; Agrylin (brand name); Anagrelide HCl; 1,5-Dihydroimidazo[2,1-b]quinazolin-2(3H)-one, 6,7-dichloro-, monohydrochloride
EINECS	Contact for details

Quality Control

Our Anagrelide Hydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment. We support compliance with major pharmacopeial standards, including USP and EP, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C
Microbial Enumeration	Complies with USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.