Description

H-Tyr-Gly-Gly-Phe-Met-Oh is a high-purity synthetic pentapeptide with the sequence Tyr-Gly-Gly-Phe-Met. This compound is of significant interest in biochemical and pharmacological research due to its structural relationship to endogenous opioid peptides. It serves as a critical reference standard and building block for advanced studies in neurochemistry and peptide drug discovery. Researchers and manufacturers in the pharmaceutical, biotechnology, and academic sectors require this material for its precise biological activity and role in developing novel therapeutic agents.

Application

• Biochemical Research: Used as a reference standard and substrate in studies of opioid receptor binding, signal transduction, and peptide metabolism.
• Pharmaceutical Development: Serves as a key intermediate or pharmacophore in the design and synthesis of novel analgesic and neuroactive peptide-based drug candidates.
• Neuroscience Studies: Employed in experimental models to investigate pain pathways, neurotransmitter release, and the endogenous opioid system.
• Peptide Library Synthesis: Acts as a core sequence or building block for constructing combinatorial peptide libraries for high-throughput screening.
• Analytical Standard: Essential for method development and validation in analytical techniques like HPLC and LC-MS for quantifying related peptides in biological matrices.
• Enzyme Substrate: Utilized in assays to study the activity and inhibition of peptidases and other enzymes involved in peptide processing.

Basic Information

Product Name	H-Tyr-Gly-Gly-Phe-Met-Oh
CAS No.	58569-55-4
Molecular Formula	C30H39N5O7S
Molecular Weight	613.73 g/mol
Synonyms	Tyr-Gly-Gly-Phe-Met; YGGFM; H-Tyr-Gly-Gly-Phe-Met-OH; L-Tyrosylglycylglycyl-L-phenylalanyl-L-methionine; Methionine Enkephalin Precursor; Opioid Pentapeptide Fragment; [Met5]-Enkephalin Related Peptide; Pentapeptide YGGFM
EINECS	Contact for details

Quality Control

Our H-Tyr-Gly-Gly-Phe-Met-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, it should be allowed to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake and degradation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to theoretical values
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.