Description

L-Homohistidine is a non-proteinogenic amino acid derivative of histidine, characterized by an additional methylene group in its side chain. This structural modification makes it a valuable chiral building block and biochemical research tool for studying enzyme mechanisms and metabolic pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide synthesis, medicinal chemistry, and the development of novel bioactive compounds. The product is supplied as a high-purity material suitable for demanding applications.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel peptide-based drugs and enzyme inhibitors.
• Biochemical Studies: Used as a substrate or analog to investigate the function and specificity of histidine-utilizing enzymes.
• Peptide Synthesis: Serves as a specialized, non-standard amino acid for constructing custom peptides with modified properties.
• Metabolic Pathway Analysis: Employed as a tracer or probe in studies of amino acid metabolism and related disorders.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	L-Homohistidine
CAS No.	58501-47-6
Molecular Formula	C7H11N3O2
Molecular Weight	169.18 g/mol
Synonyms	(S)-2-Amino-4-(1H-imidazol-4-yl)butanoic acid; L-2-Amino-4-(imidazol-4-yl)butyric acid; HhH; Homo-L-histidine; (S)-Homohistidine; 4-(1H-Imidazol-4-yl)-L-homoalanine; L-α-Amino-γ-(4-imidazolyl)butyric acid
EINECS	Contact for details

Quality Control

Our L-Homohistidine is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.