Description

Dehydrohistidinohydroxymerodesmosine is a specialized biochemical compound, a cross-linked amino acid derivative formed from lysine and histidine residues. This compound matters as a key biomarker and research tool for studying advanced glycation end-products (AGEs) and collagen cross-linking, processes critical to understanding tissue aging, diabetes complications, and connective tissue disorders. It is needed by researchers and developers in the fields of biochemistry, analytical chemistry, and life sciences for diagnostic assay development, metabolic pathway research, and as a reference standard in mass spectrometry and chromatography.

Application

• Biochemical Research Standard: Serves as a high-purity reference standard for the quantification and identification of advanced glycation end-products (AGEs) in biological samples.
• Diagnostic Development: Used in the development and calibration of diagnostic assays and kits targeting collagen cross-links and AGEs related to diabetes and aging.
• Metabolic Pathway Analysis: A critical tool for studying the Maillard reaction and non-enzymatic collagen cross-linking pathways in vitro.
• Pharmaceutical Research: Employed in drug discovery programs aimed at inhibiting AGE formation or breaking cross-links for therapeutic applications.
• Mass Spectrometry & Chromatography: Essential as an internal or external standard for LC-MS/MS, HPLC, and other analytical techniques in proteomics and metabolomics.
• Connective Tissue Studies: Used in research focused on the biochemistry of skin, bone, and vascular tissue aging and related pathologies.

Basic Information

Product Name	Dehydrohistidinohydroxymerodesmosine
CAS No.	58402-48-5
Molecular Formula	C21H32N6O7
Molecular Weight	480.52 g/mol
Synonyms	Dehydro-Histidinohydroxymerodesmosine; Dehydro-HHMD; Histidinohydroxymerodesmosine, dehydro-; AGE Cross-link; Advanced Glycation End-product Cross-link; Lysine-Histidine Cross-link; Pyridinium Compound Cross-link; Non-enzymatic Collagen Cross-link
EINECS	Contact for details

Quality Control

Our Dehydrohistidinohydroxymerodesmosine is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive analytical and research applications. Each lot undergoes comprehensive analysis including identification by spectroscopic methods, purity assessment by HPLC, and verification of molecular weight. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our rigorous internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.