Description

(S)-5-Methoxy-1,2,3,4-Tetrahydro-n-(Phenylmethyl)- 2-Naphthalenamine (Rotigotine) is a high-purity, non-ergoline dopamine agonist with significant pharmacological activity. This compound is critical for pharmaceutical research and development, particularly in the formulation of advanced neurological therapies. It is primarily required by pharmaceutical manufacturers and advanced research institutions for the development and production of treatments for Parkinson's disease and Restless Legs Syndrome (RLS).

Application

• Active Pharmaceutical Ingredient (API) in the manufacture of transdermal patches for Parkinson's disease treatment.
• Reference Standard for analytical method development and quality control in pharmaceutical laboratories.
• Pharmacological Research for studying dopamine D2 receptor agonists and their effects on the central nervous system.
• Process Chemistry & Development for optimizing synthetic routes and scaling up production.
• Formulation Studies for developing novel drug delivery systems beyond transdermal patches.
• Impurity Profiling as a key intermediate or marker in the synthesis and purification of related compounds.

Basic Information

Product Name	(S)-5-Methoxy-1,2,3,4-Tetrahydro-n-(Phenylmethyl)- 2-Naphthalenamine (Rotigotine)
CAS No.	58349-23-8
Molecular Formula	C19H25NO
Molecular Weight	283.41 g/mol
Synonyms	Rotigotine; (S)-(-)-N-0474; (S)-2-(N-Propyl-N-2-thienylethylamino)-5-hydroxytetralin; (5S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol; N-0923; (-)-N-0437; (S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol
EINECS	Contact for details

Quality Control

Our Rotigotine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. We adhere to ICH Q7 guidelines and can supply material that meets in-house specifications aligned with pharmacopeial standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Optical Rotation	[α]20/D: Contact for details
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.