Description

Amatoxin CAS NO 58250-15-0 is a potent cyclic peptide toxin belonging to the amatoxin family, primarily known for its severe hepatotoxicity. This compound is of critical importance in biochemical and pharmacological research for studying RNA polymerase II inhibition and mechanisms of acute liver failure. It is an essential reference standard and research tool for toxicologists, forensic scientists, and pharmaceutical developers working on antidotes and diagnostic assays.

Application

• Biomedical Research: Used as a highly specific inhibitor of RNA polymerase II in molecular biology studies to investigate transcription mechanisms.
• Toxicology Studies: Serves as a critical reference standard in the analysis of mushroom poisoning (e.g., from *Amanita phalloides*) and the development of diagnostic methods.
• Pharmacology Development: Employed in research aimed at understanding hepatotoxicity and for screening potential therapeutic antidotes.
• Forensic Analysis: Utilized as a calibration standard in forensic laboratories for the precise identification and quantification of amatoxins in biological and environmental samples.
• Academic Reference: Provides a pure compound for university and institutional research into mycotoxins and natural product chemistry.

Basic Information

Product Name	Amatoxin
CAS No.	58250-15-0
Molecular Formula	C39H54N10O13S
Molecular Weight	902.98 g/mol
Synonyms	α-Amanitin; α-Amanitin; Amanitin, α-; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-[(2R)-2-Butyl-3,4-dihydroxy-1-oxo-2H-pyrrol-5-yl]-6,9,21,24,33-pentaisobutyl-3,15,18-tris(1-hydroxyethyl)-12-(1-methyl-2-oxo-2-pyrrolidinylethyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; Amatoxin alpha; NSC 529010
EINECS	Contact for details

Quality Control

Our Amatoxin is produced and handled under strict quality protocols to ensure the highest purity and consistency for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for high-purity biochemical reagents to guarantee reliable and reproducible results in sensitive analytical and experimental settings.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.