Description

Isepamicine is a semi-synthetic aminoglycoside antibiotic derived from gentamicin B1, known for its potent activity against a broad spectrum of Gram-negative and some Gram-positive bacteria. Its value lies in its efficacy against strains resistant to other aminoglycosides, making it a critical agent in combating serious infections. This compound is essential for pharmaceutical R&D, reference standard preparation, and the synthesis of advanced antimicrobial agents.

Application

• Pharmaceutical Active Ingredient: Used in the research and development of injectable antibiotic formulations for systemic infections.
• Microbiological Research: Serves as a key reference standard in studies of bacterial resistance mechanisms and aminoglycoside pharmacology.
• Veterinary Medicine: Employed in the development of treatments for bacterial infections in livestock and companion animals.
• Analytical Standard: Provides a high-purity benchmark for quality control testing in pharmaceutical manufacturing and regulatory compliance.
• Intermediate Synthesis: Acts as a crucial starting material or intermediate for the chemical synthesis of novel antibiotic derivatives.

Basic Information

Product Name	Isepamicine
CAS No.	58152-03-7
Molecular Formula	C22H43N5O12
Molecular Weight	569.60 g/mol
Synonyms	Isepamicin; Sch 21420; 1-N-[(S)-4-Amino-2-hydroxybutyryl]-gentamicin B1; Antibiotic Sch 21420; (2S)-4-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-{[(2S,3R)-3-amino-6-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-2-{[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide
EINECS	Contact for details

Quality Control

Our Isepamicine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent limits for related substances and residual solvents. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure compliance with pharmaceutical research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	+120° to +130° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.