Description

O,n-Di(Trifluoroacetyl)-L-Threonine 1-Methylpropyl Ester is a high-purity, advanced chiral intermediate and derivatization reagent. This compound is critical for the synthesis and analysis of complex bioactive molecules, offering exceptional utility in stereoselective chemistry. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on peptide mimetics, prodrug development, and analytical method development.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel peptide-based drugs and enzyme inhibitors.
• Analytical Derivatization Agent: Used in chromatography (GC, LC) to enhance the detection and separation of amino acids and related compounds.
• Prodrug Synthesis: Employed in the design and preparation of prodrug candidates to improve pharmacokinetic properties.
• Bioconjugation Chemistry: Serves as a reagent for introducing trifluoroacetyl-protected threonine motifs into larger biomolecules.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or template in stereocontrolled organic reactions.
• Research & Development: Essential for academic and industrial research in medicinal chemistry and chemical biology.

Basic Information

Product Name	O,n-Di(Trifluoroacetyl)-L-Threonine 1-Methylpropyl Ester
CAS No.	57983-18-3
Molecular Formula	C13H17F6NO6
Molecular Weight	397.27 g/mol
Synonyms	L-Threonine, O,N-bis(trifluoroacetyl)-, 1-methylpropyl ester; 1-Methylpropyl O,N-bis(trifluoroacetyl)-L-threoninate; sec-Butyl O,N-bis(trifluoroacetyl)-L-threoninate; O,N-Bis(trifluoroacetyl)-L-threonine sec-butyl ester; Di(trifluoroacetyl)-L-threonine 1-methylpropyl ester; (2S,3R)-2-[(2,2,2-Trifluoroacetyl)amino]-3-[(2,2,2-trifluoroacetyl)oxy]butanoic acid 1-methylpropyl ester
EINECS	Contact for details

Quality Control

Our O,n-Di(Trifluoroacetyl)-L-Threonine 1-Methylpropyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.