Description

4-(2,2,2-Trifluoroethoxy)Aniline is a high-purity, specialized aromatic amine derivative featuring a trifluoroethoxy substituent, serving as a critical building block in advanced organic synthesis. This compound is valued for its unique electronic properties imparted by the fluorine atoms, which are essential for modulating the biological activity and physicochemical characteristics of target molecules. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoroethoxy group enhances lipophilicity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce aniline functionality into polymer backbones, creating specialty polymers with tailored surface and electronic properties.
• Dye & Pigment Manufacturing: Acts as an intermediate in the production of specialized, high-performance dyes and pigments.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) for constructing complex nitrogen-containing heterocycles.

Basic Information

Product Name	4-(2,2,2-Trifluoroethoxy)Aniline
CAS No.	57946-61-9
Molecular Formula	C8H8F3NO
Molecular Weight	191.15 g/mol
Synonyms	4-(2,2,2-Trifluoroethoxy)benzenamine; 4-Amino-2,2,2-trifluoroethoxybenzene; 1-Amino-4-(2,2,2-trifluoroethoxy)benzene; p-(2,2,2-Trifluoroethoxy)aniline; 4-Trifluoroethoxyaniline; Benzenamine, 4-(2,2,2-trifluoroethoxy)-; 57946-61-9; Aniline, 4-(2,2,2-trifluoroethoxy)-
EINECS	Contact for details

Quality Control

Every batch of 4-(2,2,2-Trifluoroethoxy)Aniline is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, and NMR to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.