Description

Fenobam CAS NO 57653-26-6 is a selective and potent non-competitive antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5). This compound is a critical research tool for investigating neurological pathways and has significant potential in the development of novel therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, pain management, and neuropsychiatric disorders.

Application

• Neuroscience Research: A key pharmacological tool for studying the role of mGluR5 in synaptic plasticity, learning, and memory.
• Drug Discovery & Development: Serves as a reference compound and lead structure for developing new treatments targeting mGluR5-related conditions.
• Preclinical Studies: Used in animal models to investigate potential therapies for anxiety, Fragile X syndrome, chronic pain, and Parkinson's disease.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro binding studies to identify and characterize new mGluR5 modulators.
• Academic & Institutional Research: Fundamental for basic science exploring glutamate receptor function and signal transduction mechanisms.

Basic Information

Product Name	Fenobam
CAS No.	57653-26-6
Molecular Formula	C11H11FN4O
Molecular Weight	234.23 g/mol
Synonyms	N-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea; McN-3377; AFQ-056 (developmental code); mGluR5 antagonist; 1-(3-Chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea
EINECS	Contact for details

Quality Control

Our Fenobam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR, and mass spectrometry for structural confirmation, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.