Description

1-Propanamine, 2-7-Chloro-5-(2-Chlorophenyl)-3H-1,4-Benzodiazepin-2-Ylthio-N,n-Dimethyl- is a high-purity, advanced pharmaceutical intermediate of significant importance in modern medicinal chemistry. This compound is valued for its role as a key synthetic precursor in the development of active pharmaceutical ingredients (APIs), particularly within the benzodiazepine class. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the synthesis and process development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of proprietary benzodiazepine-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the discovery and structure-activity relationship (SAR) studies of new central nervous system (CNS) targeting compounds.
• Process Chemistry: Serves as a standard reference material and a key starting material (KSM) for optimizing scalable synthetic routes in pilot plants and commercial manufacturing.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial drug substances.

Basic Information

Product Name	1-Propanamine, 2-7-Chloro-5-(2-Chlorophenyl)-3H-1,4-Benzodiazepin-2-Ylthio-N,n-Dimethyl-
CAS No.	57616-63-4
Molecular Formula	C20H21Cl2N3S
Molecular Weight	406.37 g/mol
Synonyms	2-[(7-Chloro-5-(2-chlorophenyl)-1,4-benzodiazepin-2-yl)thio]-N,N-dimethylpropan-1-amine; 2-[(7-Chloro-5-o-chlorophenyl-3H-1,4-benzodiazepin-2-yl)thio]-N,N-dimethylpropylamine; Lofendazam Impurity; Lofendazam Related Compound; Benzodiazepine Derivative Intermediate
EINECS	Contact for details

Quality Control

Our production of this pharmaceutical intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.