Description

S-Nitrosoglutathione (GSNO) is a critical endogenous S-nitrosothiol that serves as a major biological reservoir and transporter of nitric oxide (NO). This compound matters significantly for researchers and manufacturers as it provides a stable, physiologically relevant means to study and modulate NO-mediated signaling pathways, which are central to cardiovascular, neurological, and immune system functions. It is primarily needed by the pharmaceutical, biotechnology, and life science research sectors for applications in drug discovery, biochemical research, and the development of novel therapeutic agents targeting NO biology.

Application

• Biochemical Research: A key tool for studying nitric oxide (NO) signaling, protein S-nitrosylation, and redox biology in cellular and in vitro systems.
• Pharmaceutical Development: Investigated as a potential therapeutic agent or prodrug for conditions involving dysfunctional NO signaling, such as cardiovascular diseases, pulmonary hypertension, and platelet aggregation disorders.
• Cell Biology Studies: Used to induce controlled nitrosative stress or to deliver NO to specific cellular compartments to study apoptosis, vasodilation, and immune response mechanisms.
• Enzymology: Serves as a substrate for enzymes like glutathione-dependent formaldehyde dehydrogenase (GS-FDH) and as a regulator of enzyme activity through S-nitrosylation.
• Neuroscience Research: Employed to explore the role of NO in neurotransmission, neuroprotection, and neurodegenerative diseases.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and other analytical methods for quality control and method validation.

Basic Information

Product Name	S-Nitrosoglutathione
CAS No.	57564-91-7
Molecular Formula	C10H16N4O7S
Molecular Weight	336.32 g/mol
Synonyms	GSNO; S-Nitroso-GSH; Glutathione, S-nitroso-; L-γ-Glutamyl-S-nitroso-L-cysteinylglycine; Nitrosoglutathione; S-Nitroso-L-glutathione; (2S)-2-Amino-4-[[(1R)-1-[(carboxymethyl)carbamoyl]-2-(nitrososulfanyl)ethyl]carbamoyl]butanoic acid
EINECS	Contact for details

Quality Control

Our S-Nitrosoglutathione is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity for research and development purposes. Each lot undergoes comprehensive analytical testing, including HPLC for purity and assay, verification of S-nitrosothiol content, and identity confirmation by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). The product is light-sensitive and easily oxidized; therefore, it should be handled in a controlled environment to minimize exposure to light, moisture, and air. Allow the vial to reach room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Pale yellow to pink powder or crystalline solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 95%
S-Nitrosothiol Content	≥ 90%
Free Glutathione (HPLC)	≤ 3.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in water, DMSO; slightly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.