Description

N'-Methyl-L-Histidine Methyl Ester is a chemically modified derivative of the amino acid L-histidine, featuring methylation at the imidazole nitrogen and esterification of the carboxyl group. This specific modification is crucial for advanced research and synthesis, particularly in the study of histidine metabolism and the development of novel bioactive compounds. It serves as a valuable building block and analytical standard for pharmaceutical R&D, biochemical research, and proteomics laboratories requiring high-purity, well-characterized intermediates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates, particularly those targeting neurological or metabolic pathways.
• Biochemical Research: Used as a standard or reagent in enzymatic studies, metabolic pathway analysis, and investigations into histidine-related biological processes.
• Proteomics & Peptide Synthesis: Serves as a protected or modified amino acid derivative in the solid-phase or solution-phase synthesis of specialized peptides and mimetics.
• Analytical Reference Standard: Employed in HPLC, LC-MS, and NMR for method development, calibration, and quantification in analytical laboratories.
• Metabolite Studies: Critical for research into histidine metabolism, including the study of methylation patterns and related biomarkers.
• Academic & Institutional R&D: A fundamental research chemical for universities and institutes exploring amino acid chemistry and protein function.

Basic Information

Product Name	N'-Methyl-L-Histidine Methyl Ester
CAS No.	57519-09-2
Molecular Formula	C9H15N3O2
Molecular Weight	197.24 g/mol
Synonyms	L-Histidine, N(pi)-methyl-, methyl ester; Methyl N(pi)-methyl-L-histidinate; 1-Methyl-L-histidine methyl ester; (2S)-2-Amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid methyl ester; Nπ-Methyl-L-histidine methyl ester; Methyl 1-methyl-L-histidinate; N(tau)-Methyl-L-histidine methyl ester; N(τ)-Methyl-L-histidine methyl ester
EINECS	Contact for details

Quality Control

Our N'-Methyl-L-Histidine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]D20: Specific range available on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.