Description

Substance P (1-9) CAS NO 57468-17-4 is a specific, biologically active fragment of the full neuropeptide Substance P, comprising its first nine amino acids. This peptide fragment is a critical research tool for studying neurokinin-1 (NK1) receptor interactions, inflammation, and pain signaling pathways. It is essential for researchers and developers in the fields of neuroscience, pharmacology, and drug discovery who require high-purity, well-characterized peptide reagents for in vitro and in vivo studies.

Application

• Neuroscience Research: Used as a selective agonist to study the role of the NK1 receptor in pain transmission, neurogenic inflammation, and central nervous system disorders.
• Pharmacological Assay Development: Serves as a standard and control in high-throughput screening (HTS) assays designed to identify novel NK1 receptor antagonists.
• Cell Signaling Studies: Applied in cell culture models to investigate intracellular signaling cascades triggered by NK1 receptor activation.
• Inflammation Research: Utilized in experimental models to explore the peptide's role in mediating inflammatory responses and vascular permeability.
• Biochemical Reagent: Acts as a key substrate or ligand in enzymatic studies, receptor binding assays, and structure-activity relationship (SAR) analyses.
• Reference Standard: Provides a certified reference material for the quality control and validation of other Substance P-related peptides and assay kits.

Basic Information

Product Name	Substance P (1-9)
CAS No.	57468-17-4
Molecular Formula	C53H78N16O12S
Molecular Weight	1131.34 g/mol
Synonyms	Substance P Fragment 1-9; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly; H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-OH; SP (1-9); Neurokinin P (1-9); Tachykinin Fragment 1-9
EINECS	Contact for details

Quality Control

Our Substance P (1-9) is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake, and handle under an inert atmosphere when possible for critical applications.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.