Description

Substance P (1-4) CAS NO 57468-16-3 is a defined fragment of the neuropeptide Substance P, specifically encompassing the first four amino acids (Arg-Pro-Lys-Pro) of its N-terminal sequence. This peptide fragment is a critical research tool for studying the structure-activity relationships and biological functions of the full-length neuropeptide. It is primarily utilized by researchers and developers in the fields of neuroscience, pharmacology, and peptide chemistry for biochemical assays, receptor binding studies, and as a reference standard.

Application

• Neuroscience Research: Used as a selective ligand and reference compound in studies of neurokinin-1 (NK1) receptor interactions and signaling pathways.
• Pharmacological Studies: Employed in competitive binding assays to evaluate the potency and selectivity of novel Substance P antagonists or agonists.
• Biochemical Assay Standard: Serves as a high-purity calibrant and control in analytical methods such as HPLC and mass spectrometry for peptide quantification.
• Structure-Activity Relationship (SAR) Analysis: Essential for mapping the bioactive regions of the full Substance P peptide to understand its pharmacophore.
• Enzyme Substrate: Can be used in studies investigating the metabolism and degradation of Substance P by peptidases.
• Cell Culture & In Vitro Studies: Applied in cellular models to investigate the localized effects of Substance P fragments on inflammation, pain transmission, and other physiological processes.

Basic Information

Product Name	Substance P (1-4)
CAS No.	57468-16-3
Molecular Formula	C23H41N9O5
Molecular Weight	523.64 g/mol
Synonyms	Substance P Fragment 1-4; Arg-Pro-Lys-Pro; SP(1-4); H-Arg-Pro-Lys-Pro-OH; Substance P (1-4) amide (common reference); Neurokinin P (1-4); Tachykinin fragment 1-4
EINECS	Contact for details

Quality Control

Our Substance P (1-4) is produced under stringent conditions to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.