Description

Heparin Monosulfate Sodium Salt is a chemically modified derivative of the natural anticoagulant heparin, standardized to a monosulfate form. This modification offers a more defined and consistent molecular profile compared to native heparin, which is critical for research and specialized applications requiring precise biological activity. It is essential for biochemical research, pharmaceutical development, and as a key intermediate in the production of low molecular weight heparins. This product is supplied as a high-purity material to meet the stringent demands of the life sciences and pharmaceutical industries.

Application

• Biochemical Research: Used as a standard or substrate in enzymatic studies, particularly those involving heparinases and sulfatases.
• Pharmaceutical Intermediates: Serves as a critical starting material for the synthesis of low molecular weight heparin (LMWH) derivatives and other heparin-based therapeutics.
• Cell Culture & Tissue Engineering: Employed to modify surfaces or incorporate into hydrogels to study and modulate cell growth, differentiation, and angiogenesis.
• Anticoagulant Activity Studies: Used in vitro to investigate structure-activity relationships (SAR) of heparin derivatives and their interaction with antithrombin III and other plasma proteins.
• Diagnostic Reagent Production: A component in the formulation of certain diagnostic kits and assays that measure clotting factors or heparin levels.
• Glycosaminoglycan (GAG) Analysis: Acts as a reference standard in chromatographic (e.g., HPLC, CE) and spectroscopic analyses for GAG characterization.

Basic Information

Product Name	Heparin Monosulfate Sodium Salt
CAS No.	57459-72-0
Molecular Formula	Contact for details
Molecular Weight	Variable (Polymer)
Synonyms	Heparin Monosulfate, Sodium Salt; Heparin, Monosulfate, Sodium Salt; Monosulfated Heparin Sodium; Sodium Heparin Monosulfate; Heparin Sodium Monosulfate; Heparitin Monosulfate Sodium Salt; Heparin Monosulfate (Na Salt)
EINECS	Contact for details

Quality Control

Our Heparin Monosulfate Sodium Salt is manufactured under strict quality systems. Each batch is tested to ensure identity, purity, and biological consistency. We provide comprehensive analytical data including potency (anti-Factor Xa/IIa activity), sulfate content, and molecular weight distribution. Certificates of Analysis (COA) documenting these specifications are available for every lot. The product is suitable for research and development use under current Good Manufacturing Practice (cGMP) guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to standard
Assay (Potency)	≥ 90% (by anti-Factor Xa activity)
Sulfur Content	Contact for details
Protein Content	≤ 1.0%
Loss on Drying	≤ 10.0%
pH (1% Solution)	5.0 - 7.5
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.