Description

1,3-Dimethyl-5-[(Trimethylsiloxy)Methyl]-2,4(1H,3H)-Pyrimidinedione is a specialized organosilicon-modified pyrimidinedione derivative. This compound is valued for its role as a key synthetic intermediate and protecting group reagent in advanced organic synthesis. It is primarily sought by research and development teams in the pharmaceutical and fine chemical industries for the production of nucleoside analogs and other high-value active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of modified nucleosides and antiviral/anticancer drug candidates.
• Protecting Group Reagent: The trimethylsiloxy (TMS) group serves to protect hydroxyl functionalities during complex multi-step synthetic routes.
• Fine Chemical Synthesis: Used in the research and development of novel heterocyclic compounds for agrochemicals and specialty materials.
• Biochemical Research: Employed in the study of nucleic acid chemistry and the development of diagnostic probes.
• Process Chemistry: Utilized in scale-up and optimization of API manufacturing processes under GMP conditions.

Basic Information

Product Name	1,3-Dimethyl-5-[(Trimethylsiloxy)Methyl]-2,4(1H,3H)-Pyrimidinedione
CAS No.	57396-82-4
Molecular Formula	C10H18N2O3Si
Molecular Weight	242.35 g/mol
Synonyms	5-[(Trimethylsilyloxy)methyl]-1,3-dimethyluracil; 1,3-Dimethyl-5-((trimethylsilyloxy)methyl)uracil; 5-(Hydroxymethyl)-1,3-dimethyluracil trimethylsilyl ether; 5-((Trimethylsiloxy)methyl)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione; TMS ether of 5-(Hydroxymethyl)-1,3-dimethyluracil; NSC 339586
EINECS	Contact for details

Quality Control

Our 1,3-Dimethyl-5-[(Trimethylsiloxy)Methyl]-2,4(1H,3H)-Pyrimidinedione is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical R&D and fine chemical synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.