Description

n-o-Dicarbobenzoxy-L-Tyrosine is a protected derivative of the essential amino acid L-Tyrosine, where both the amino and phenolic hydroxyl groups are blocked with carbobenzoxy (Cbz) protecting groups. This compound is of critical importance in peptide synthesis, particularly in solid-phase and solution-phase methodologies, where it serves as a key building block for introducing tyrosine residues while preventing unwanted side reactions. It is primarily needed by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the production of complex peptides, peptide hormones, and novel therapeutic agents.

Application

• Peptide Synthesis: A fundamental protected amino acid for the stepwise construction of peptide chains in both research and commercial-scale production.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Biochemical Research: Used in academic and industrial R&D for studying protein structure-function relationships, enzyme substrates, and signal transduction pathways.
• Production of Peptide Hormones: A key raw material in the synthesis of tyrosine-containing peptide hormones and related analogs.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for drug discovery and screening applications.
• Fine Chemical Manufacturing: Utilized as a specialized intermediate for custom synthesis and contract manufacturing of complex organic molecules.

Basic Information

Product Name	n-o-Dicarbobenzoxy-L-Tyrosine
CAS No.	57228-29-2
Molecular Formula	C26H25NO7
Molecular Weight	463.48 g/mol
Synonyms	N,O-Bis(carbobenzoxy)-L-tyrosine; N,O-Di-Cbz-L-tyrosine; L-Tyrosine, N,O-bis[(phenylmethoxy)carbonyl]-; N-Carbobenzoxy-O-carbobenzoxy-L-tyrosine; Boc-Tyr(Bzl)-OH (common misnomer, correctly refers to Boc protection); Z-Tyr(Z)-OH; (2S)-2-[[(Benzyloxy)carbonyl]amino]-3-[4-[[(benzyloxy)carbonyl]oxy]phenyl]propanoic acid; Bis-Cbz-L-Tyrosine
EINECS	Contact for details

Quality Control

Our n-o-Dicarbobenzoxy-L-Tyrosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for peptide synthesis and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as assay, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Ensure the storage area is well-ventilated and separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: Specific range provided on COA
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.