Description

γ-Methyl-L-Leucine is a non-proteinogenic amino acid derivative characterized by a methyl group on the gamma carbon of the leucine side chain. This structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel peptides and bioactive compounds. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, proteomics, and the production of specialized fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new therapeutic peptides and drug candidates.
• Peptide Synthesis: Used as a modified amino acid residue to introduce structural diversity and alter the physicochemical properties of synthetic peptides.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate metabolic pathways and protein function.
• Proteomics & Mass Spectrometry: Can be used as an internal standard or a labeled analog in quantitative proteomic analysis.
• Fine Chemical Production: Acts as a precursor in the synthesis of more complex, high-value specialty chemicals and ligands.

Basic Information

Product Name	γ-Methyl-L-Leucine
CAS No.	57224-50-7
Molecular Formula	C7H15NO2
Molecular Weight	145.20 g/mol
Synonyms	(2S)-2-Amino-4-methylpentanoic acid; L-2-Amino-4-methylpentanoic acid; L-Leucine, 4-methyl-; (S)-2-Amino-4-methylvaleric acid; γ-Methyl-L-leucine; 4-Methyl-L-leucine; L-γ-Methylleucine; (S)-4-Methyl-2-aminopentanoic acid
EINECS	Contact for details

Quality Control

Our γ-Methyl-L-Leucine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results for parameters including assay, enantiomeric purity, and specified impurities. Our quality commitment supports applications requiring high-purity standards for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.