Description

4-(2-Fluoro-Benzyloxy)-Phenylamine is a specialized aromatic amine derivative featuring a fluorinated benzyloxy substituent. This compound is valued as a key pharmaceutical intermediate and building block in advanced organic synthesis, enabling the introduction of specific functional groups into target molecules. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders or possessing specific receptor binding profiles.
• Agrochemical Synthesis: Serves as a building block for developing new herbicides, fungicides, or insecticides, where the fluorine atom can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Used in the research and preparation of novel ligands for metal-catalyzed reactions or as a component in catalyst design for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of advanced polymers, liquid crystals, or organic electronic materials where its aromatic and amine functionalities are beneficial.
• Dye and Pigment Intermediate: Acts as a starting material for the production of specialized dyes, pigments, and colorants.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific custom synthesis projects.

Basic Information

Product Name	4-(2-Fluoro-Benzyloxy)-Phenylamine
CAS No.	57181-83-6
Molecular Formula	C₁₃H₁₂FNO
Molecular Weight	217.24 g/mol
Synonyms	4-[(2-Fluorophenyl)methoxy]aniline; 4-(2-Fluorobenzyloxy)aniline; Benzenamine, 4-[(2-fluorophenyl)methoxy]-; 2-Fluorobenzyl 4-aminophenyl ether; 4-Aminophenyl 2-fluorobenzyl ether; 1-Fluoro-2-[(4-aminophenoxy)methyl]benzene; 4-(2-Fluorobenzyloxy)phenylamine; 2-Fluoro-α-[(4-aminophenoxy)methyl]benzene
EINECS	Contact for details

Quality Control

Our 4-(2-Fluoro-Benzyloxy)-Phenylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent quality. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.