Description

Bradykinin, 4-Nitro-Phe(5)- is a chemically modified analog of the endogenous vasoactive peptide bradykinin, specifically incorporating a 4-nitrophenylalanine residue at position 5. This modification is critical for research into the structure-activity relationships of kinin receptors and the development of selective receptor antagonists or agonists. It is an essential biochemical tool for pharmaceutical R&D and academic laboratories focused on cardiovascular pharmacology, inflammation, and pain signaling pathways.

Application

• Pharmacological Research: Used as a key reference standard and probe in studies of B1 and B2 bradykinin receptor subtypes to understand their roles in inflammation, pain, and vascular permeability.
• Drug Discovery & Development: Serves as a critical intermediate or analog in the design and screening of novel therapeutic agents targeting kinin-mediated pathways for conditions like hypertension, angioedema, and chronic pain.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening (HTS) assays, ELISA tests, and radioimmunoassays (RIA) for kinin system analysis.
• Academic & Institutional Research: Provides a fundamental tool for mechanistic studies in physiology and cell biology, investigating peptide-receptor interactions and downstream signal transduction.
• Peptide Chemistry Studies: Acts as a model compound in research focused on peptide synthesis, stability, and the effects of specific amino acid modifications on biological activity.

Basic Information

Product Name	Bradykinin, 4-Nitro-Phe(5)-
CAS No.	57164-28-0
Molecular Formula	C50H73N15O13
Molecular Weight	1084.2 g/mol
Synonyms	4-Nitro-Phe5-Bradykinin; [4-NO2-Phe5]-Bradykinin; Bradykinin, 4-Nitro-L-phenylalanine-5-; H-Arg-Pro-Pro-Gly-Phe(4-NO2)-Ser-Pro-Phe-Arg-OH; 4-Nitrophenylalanine5-bradykinin; BK (4-Nitro-Phe5); [Phe5(4-NO2)]-Bradykinin
EINECS	Contact for details

Quality Control

Every batch of Bradykinin, 4-Nitro-Phe(5)- is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for critical research applications. A Certificate of Analysis (COA) detailing specifications such as purity (HPLC), peptide content, and identity confirmation is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Amino Acid Analysis	Within ± 10% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.