Description

Boc-Orn(Boc)-Oh is a protected derivative of the amino acid ornithine, widely used as a crucial building block in solid-phase peptide synthesis (SPPS). This compound matters for its role in facilitating the controlled elongation of peptide chains, where the tert-butoxycarbonyl (Boc) groups provide essential protection for the amino and side-chain functionalities. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, bioactive compounds, and complex organic molecules.

Application

• Peptide Synthesis: A fundamental building block (amino acid derivative) for the controlled synthesis of peptides and proteins in research and development.
• Pharmaceutical Intermediates: Serves as a key intermediate in the production of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation: Used in the preparation of modified peptides for bioconjugation applications, such as creating peptide-drug conjugates or labeled probes.
• Chemical Biology Research: Employed in studies exploring protein-protein interactions, enzyme substrates, and the structure-activity relationships of peptides.
• Combinatorial Chemistry: A valuable reagent in libraries for high-throughput screening to discover new biologically active molecules.
• Protecting Group Chemistry: Demonstrates the application of Boc-protection strategies, which are pivotal in multi-step organic syntheses requiring orthogonal protection.

Basic Information

Product Name	Boc-Orn(Boc)-Oh
CAS No.	57133-29-6
Molecular Formula	C₁₅H₂₈N₂O₆
Molecular Weight	332.40 g/mol
Synonyms	Nα,Nδ-Bis(tert-butoxycarbonyl)-L-ornithine; Nα-Boc-Nδ-Boc-L-ornithine; Boc-Orn(Boc)-OH; (S)-2-((tert-Butoxycarbonyl)amino)-5-((tert-butoxycarbonyl)amino)pentanoic acid; H-Orn(Boc)-Boc-OH; L-Ornithine, N2,N5-bis[(1,1-dimethylethoxy)carbonyl]-; Boc-L-Orn(Boc)-OH; BOC-ORN(BOC)-OH
EINECS	Contact for details

Quality Control

Our Boc-Orn(Boc)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, specific rotation, and residual solvent levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.5%
Optical Rotation	-10.0° to -12.0° (c=1 in Acetic Acid)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.