Description

Z-Glu(Otbu)-Ome is a protected amino acid derivative, specifically the benzyloxycarbonyl (Z) protected glutamic acid with its γ-carboxyl group as a tert-butyl ester and its α-carboxyl group as a methyl ester. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled and sequential assembly of complex peptides. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers involved in developing therapeutic peptides, biochemical probes, and novel materials.

Application

• Peptide Synthesis: A key intermediate for the controlled incorporation of glutamic acid residues during Fmoc- or Boc-based solid-phase peptide synthesis.
• Pharmaceutical Research: Used in the development and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Serves as a starting material for creating linkers or modified amino acids used in antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology: Employed in the synthesis of custom peptides for studying protein-protein interactions, enzyme substrates, and inhibitors.
• Material Science: Acts as a monomer or precursor for designing peptide-based polymers, hydrogels, and other biomimetic materials.

Basic Information

Product Name	Z-Glu(Otbu)-Ome
CAS No.	56877-41-9
Molecular Formula	C18H25NO6
Molecular Weight	351.40 g/mol
Synonyms	N-Cbz-L-glutamic acid α-methyl γ-tert-butyl ester; Nα-Benzyloxycarbonyl-L-glutamic acid 1-methyl 5-tert-butyl ester; Z-L-Glu(OMe)-OtBu; Z-Glu(OBut)-OMe; Z-Glu(OtBu)-OMe; Cbz-Glu(OtBu)-OMe; N-Carbobenzoxy-L-glutamic acid α-methyl γ-tert-butyl ester; L-Glutamic acid, N-[(phenylmethoxy)carbonyl]-, 1-methyl 5-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our Z-Glu(Otbu)-Ome is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) with detailed specifications are provided to ensure the material meets the stringent requirements for pharmaceutical research and peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.