Description

Angiotensin II, Sar(1)-Thr(8)- is a synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, modified to enhance receptor binding affinity and stability. This compound is a critical research tool for studying the renin-angiotensin system (RAS), which regulates blood pressure, fluid balance, and cardiovascular function. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cardiovascular disease research, drug discovery, and biochemical assay development.

Application

• Biomedical Research: Fundamental studies on the physiology and pharmacology of the renin-angiotensin system (RAS).
• Drug Discovery & Screening: Used as a reference standard or target ligand in high-throughput screening (HTS) assays for identifying novel antihypertensive agents.
• Receptor Binding Assays: Investigating the binding kinetics and affinity for Angiotensin II type 1 (AT1) and type 2 (AT2) receptors.
• Signal Transduction Studies: Elucidating intracellular pathways activated by Angiotensin II receptor stimulation.
• In Vitro & Ex Vivo Models: Employed in cell-based assays and isolated tissue preparations to study vascular contraction and cardiac effects.
• Standard for Analytical Methods: Serves as a calibration standard in HPLC, LC-MS, and other analytical techniques for peptide quantification and purity assessment.

Basic Information

Product Name	Angiotensin II, Sar(1)-Thr(8)-
CAS No.	56832-47-4
Molecular Formula	C₄₉H₆₉N₁₃O₁₂
Molecular Weight	1032.2 g/mol
Synonyms	[Sar¹,Thr⁸]-Angiotensin II; Saralasin Acetate; 1-Sarcosine-8-threonine Angiotensin II; Sar¹-Thr⁸-AII; Angiotensin II Antagonist (Saralasin); Sarcosine¹, Threonine⁸ Angiotensin II; Asp-Arg-Val-Tyr-Ile-His-Pro-Thr; DRVYIHP
EINECS	Contact for details

Quality Control

Our Angiotensin II, Sar(1)-Thr(8)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, and residual solvent levels are provided to ensure compliance with research-grade standards and support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	5 - 15%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.