Description

L-1-Acetyl-5-Oxoproline is a high-purity, specialized pyrrolidone derivative used as a critical building block in advanced organic synthesis. This compound matters for its role as a protected form of 5-oxoproline, enabling precise chemical transformations while maintaining the integrity of sensitive functional groups. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel peptides, prodrugs, and bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based therapeutics.
• Peptide Chemistry: Used as a protected glutamic acid derivative or a conformational constraint element in solid-phase and solution-phase peptide synthesis.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies, particularly those involving glutamine or glutamate metabolism pathways.
• Prodrug Design: Acts as a bioreversible protecting group to enhance the solubility, stability, or bioavailability of drug candidates.
• Organic Synthesis: Functions as a versatile precursor for the synthesis of more complex heterocyclic compounds and chiral auxiliaries.
• Cosmetic Ingredient Synthesis: Potential use in the synthesis of moisturizing agents or skin-conditioning compounds due to its pyrrolidone backbone.

Basic Information

Product Name	L-1-Acetyl-5-Oxoproline
CAS No.	56805-18-6
Molecular Formula	C7H9NO4
Molecular Weight	171.15 g/mol
Synonyms	1-Acetyl-L-pyroglutamic acid; N-Acetyl-L-pyroglutamic acid; (S)-1-Acetyl-5-oxopyrrolidine-2-carboxylic acid; L-Pyroglutamic acid N-acetate; Acetyl pyroglutamic acid; N-Acetyl-5-oxo-L-proline; N-Acetyl-L-2-pyrrolidone-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our L-1-Acetyl-5-Oxoproline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.