Description

n-(1-Methylethyl)-L-Norleucine 1-Methylethyl Ester is a specialized chiral amino acid derivative, specifically an ester-protected form of L-norleucine. This compound is of significant value in advanced organic synthesis and pharmaceutical research, serving as a crucial building block for the development of novel peptides and bioactive molecules. It is primarily required by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the synthesis of complex, high-value compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for peptide-based therapeutics.
• Peptide Synthesis: Used as a protected amino acid building block in solid-phase and solution-phase peptide synthesis (SPPS) to introduce modified norleucine residues.
• Chemical Biology Research: Employed in the study of protein structure and function, enzyme inhibition, and as a probe in metabolic pathway analysis.
• Agrochemical Development: Serves as an intermediate in the synthesis of specialized chiral compounds for advanced crop protection agents.
• Catalyst and Ligand Preparation: Utilized in the synthesis of novel chiral catalysts and ligands for asymmetric synthesis applications.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	n-(1-Methylethyl)-L-Norleucine 1-Methylethyl Ester
CAS No.	56771-73-4
Molecular Formula	C12H25NO2
Molecular Weight	215.33 g/mol
Synonyms	L-Norleucine, N-isopropyl-, isopropyl ester; Isopropyl N-isopropyl-L-norleucinate; N-Isopropyl-L-norleucine isopropyl ester; (S)-2-((Isopropylamino)methyl)pentanoic acid isopropyl ester; NIP-L-Nle-OiPr; (S)-Isopropyl 2-((isopropylamino)methyl)pentanoate
EINECS	Contact for details

Quality Control

Our production of n-(1-Methylethyl)-L-Norleucine 1-Methylethyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the exacting standards required for research and synthesis. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.