Description

Nα,1-Bis(1-Methylethyl)-L-Histidine 1-Methylethyl Ester is a protected derivative of the essential amino acid L-Histidine, designed for advanced synthetic applications where selective reactivity is paramount. This compound is critical for researchers and manufacturers requiring high-purity, specialized building blocks for peptide synthesis and pharmaceutical intermediate development. It is primarily utilized in the research and production of complex bioactive peptides, enzyme inhibitors, and novel therapeutic agents within the pharmaceutical, biotechnology, and advanced chemical synthesis sectors.

Application

• Pharmaceutical Intermediate: Serves as a key protected building block in the solid-phase and solution-phase synthesis of complex peptide-based drugs and therapeutic candidates.
• Peptide Research & Development: Enables the selective incorporation of histidine residues in novel peptide sequences for structure-activity relationship (SAR) studies and bioactivity screening.
• Enzyme Inhibitor Synthesis: Used in the preparation of histidine-containing analogs designed to target specific enzymatic pathways.
• Bioconjugation Chemistry: Acts as a specialized linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Probes: Employed in the synthesis of labeled peptides and probes for studying protein-protein interactions and cellular processes.
• Custom Fine Chemical Synthesis: Provides a versatile intermediate for contract research organizations (CROs) and CDMOs working on custom synthesis projects.

Basic Information

Item	Detail
Product Name	Nα,1-Bis(1-Methylethyl)-L-Histidine 1-Methylethyl Ester
CAS No.	56771-69-8
Molecular Formula	C16H29N3O2
Molecular Weight	295.42 g/mol
Synonyms	Nα-Diisopropyl-L-histidine isopropyl ester; L-Histidine, Nα,1-bis(1-methylethyl)-, 1-methylethyl ester; Diisopropyl-L-histidine isopropyl ester; Nα,N(τ)-Diisopropyl-L-histidine isopropyl ester; (S)-2-((Diisopropylamino)methyl)-1H-imidazole-1-carboxylic acid isopropyl ester; BOC-His(Diisopropyl)-O-iPr (related protected form); Protected L-Histidine derivative
EINECS	Contact for details

Quality Control

Every batch of Nα,1-Bis(1-Methylethyl)-L-Histidine 1-Methylethyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are supported by a detailed Certificate of Analysis (COA) that includes results from HPLC, NMR, and mass spectrometry. We adhere to cGMP principles where applicable to meet the stringent requirements of pharmaceutical and research customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.