Description

S-(-)-Etomidate is the single, pharmacologically active enantiomer of the short-acting intravenous anesthetic agent etomidate. This high-purity chiral compound is critical for research and development focused on improving anesthetic safety profiles and understanding receptor-specific mechanisms of action. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and manufacturers of active pharmaceutical ingredients (APIs) for advanced anesthetic formulations.

Application

• Pharmaceutical R&D: As a key chiral intermediate or reference standard in the development of new intravenous anesthetic agents and sedatives.
• Analytical Chemistry: Serves as a high-purity standard for method development and validation in chiral HPLC and LC-MS analysis.
• Pharmacology Studies: Used in preclinical research to investigate the GABAA receptor modulation and the cardiovascular stability profile of anesthetic agents.
• API Manufacturing: An essential building block in the synthesis of enantiomerically pure etomidate and related anesthetic compounds under GMP conditions.
• Metabolism and Toxicology Research: Employed in studies examining the stereoselective metabolism, pharmacokinetics, and toxicological profile of etomidate.

Basic Information

Product Name	S-(-)-Etomidate
CAS No.	56649-47-9
Molecular Formula	C14H16N2O2
Molecular Weight	244.29 g/mol
Synonyms	(S)-Etomidate; (-)-Etomidate; (S)-1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester; R-16659 (S-enantiomer); Amidate (S-enantiomer); Hypnomidate (S-enantiomer); (S)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate
EINECS	Contact for details

Quality Control

Our S-(-)-Etomidate is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We support development and commercial projects with material suitable for research use and can supply grades aligned with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (S-enantiomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.