Description

Efrapeptin CAS NO 56645-91-1 is a potent, naturally occurring peptide metabolite produced by the fungus Tolypocladium. This compound is of significant interest due to its powerful inhibitory activity against the mitochondrial F1F0-ATPase, effectively blocking ATP synthesis. It serves as a critical research tool for scientists studying bioenergetics, cellular metabolism, and the development of novel antimicrobial or pesticidal agents. Key industries that utilize this high-purity biochemical include academic and pharmaceutical research, agrochemical development, and specialized biotechnology sectors.

Application

• Biochemical Research: As a specific and potent inhibitor of mitochondrial ATP synthase (F1F0-ATPase) for studying oxidative phosphorylation, cellular energy metabolism, and ion transport.
• Antimicrobial Agent Development: Investigation of its inherent antifungal and antibacterial properties for potential use in novel therapeutic or preservative formulations.
• Agrochemical Research: Exploration of its insecticidal and acaricidal activity for the development of new, biologically derived crop protection agents.
• Cell Biology & Physiology Studies: Used to induce metabolic stress and study cell death pathways (apoptosis/necrosis) in various cell models.
• Pharmacology & Toxicology: Serves as a reference standard and tool compound for screening and mechanistic studies related to mitochondrial dysfunction.
• Enzyme Inhibition Assays: A standard inhibitor in enzymatic assays to characterize ATPase activity and screen for other modulators.

Basic Information

Product Name	Efrapeptin
CAS No.	56645-91-1
Molecular Formula	C58H95N15O13
Molecular Weight	1210.5 g/mol
Synonyms	Efrapeptin D; Antibiotic A23871; Leupeptin Bo; ATPase inhibitor, Efrapeptin; Tolypocladium metabolite; F1F0-ATPase inhibitor; [Ile6]-efrapeptin D; A 23871
EINECS	Contact for details

Quality Control

Our Efrapeptin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.