Description

Angiotensin II, Ala(7)- is a synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, modified by the substitution of alanine at the seventh position. This structural modification is critical for research into the renin-angiotensin system (RAS), receptor specificity, and metabolic pathways. It is an essential biochemical tool for pharmaceutical R&D, academic research, and diagnostic development, particularly in cardiovascular and renal disease studies.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of the renin-angiotensin-aldosterone system (RAAS), hypertension, and heart failure.
• Receptor Binding Assays: Employed to investigate the binding affinity and selectivity of Angiotensin II receptor subtypes (AT1 and AT2).
• Pharmaceutical Development: Serves as a key intermediate or reference compound in the discovery and development of cardiovascular drugs and receptor antagonists.
• Diagnostic Applications: Utilized in the development and calibration of immunoassays and diagnostic kits for measuring angiotensin-related biomarkers.
• Metabolic Pathway Studies: Applied in research to elucidate the enzymatic conversion pathways and degradation products of angiotensin peptides.
• Cell Signaling Research: Acts as a tool to study intracellular signaling cascades and physiological responses triggered by angiotensin receptor activation.

Basic Information

Product Name	Angiotensin II, Ala(7)-
CAS No.	56645-79-5
Molecular Formula	C49H69N13O11
Molecular Weight	1016.2 g/mol
Synonyms	[Ala7]-Angiotensin II; Asp-Arg-Val-Tyr-Ile-His-Ala-Phe; H-Asp-Arg-Val-Tyr-Ile-His-Ala-Phe-OH; 1-L-Aspartic acid-5-L-isoleucine-8-L-phenylalanine angiotensin II; Ala7-Ang II; Angiotensin II (1-8) heptapeptide analog; Angiotensin II Ala-7 analog
EINECS	Contact for details

Quality Control

Our Angiotensin II, Ala(7)- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.