Description

H-Leu-Gly-Otbu Hcl is a protected dipeptide derivative, specifically the tert-butyl ester hydrochloride salt of the leucine-glycine dipeptide. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS), where its protecting groups allow for selective deprotection and controlled chain elongation. It is primarily needed by pharmaceutical R&D teams, biotech companies, and fine chemical manufacturers engaged in the production of therapeutic peptides, research peptides, and complex organic molecules.

Application

• Pharmaceutical Intermediates: A key raw material in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs).
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid derivative for the controlled, sequential assembly of peptide chains on resin.
• Biochemical Research: Employed in academic and industrial laboratories for studying peptide structure, function, and metabolism.
• Proteomics & Drug Discovery: Utilized to create peptide libraries for high-throughput screening and target identification.
• Custom Peptide Synthesis: A fundamental component for CROs and CDMOs offering bespoke peptide manufacturing services.
• Conjugate Vaccine Development: Can be used in the synthesis of peptide antigens or carrier protein linkers.

Basic Information

Product Name	H-Leu-Gly-Otbu Hcl
CAS No.	56610-13-0
Molecular Formula	C13H27N2O3 • HCl
Molecular Weight	308.83 g/mol (as free base: 271.37)
Synonyms	L-Leucyl-glycine tert-butyl ester hydrochloride; H-Leu-Gly-OtBu•HCl; N-(tert-Butoxycarbonyl)-L-leucylglycine; Boc-Leu-Gly-OtBu HCl; (S)-2-((2-((tert-Butoxycarbonyl)amino)-4-methylpentanamido)acetic acid tert-butyl ester hydrochloride; Leu-Gly-OtBu hydrochloride; tert-Butyl L-leucylglycinate hydrochloride
EINECS	Contact for details

Quality Control

Our H-Leu-Gly-Otbu Hcl is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and GMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]	-XX° to -XX° (c=1, MeOH)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.