Description

Cyclo(-His-Phe) is a cyclic dipeptide, also known as a diketopiperazine (DKP), formed from the amino acids L-Histidine and L-Phenylalanine. This compound is of significant interest in pharmaceutical research and development due to its role as a potential bioactive scaffold and a degradation product of larger peptide drugs. It serves as a critical intermediate and reference standard for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors, where precise molecular structure and high purity are paramount.

Application

• Pharmaceutical Reference Standard: Used for the identification, purity testing, and quantification in analytical methods (HPLC, LC-MS) for peptide-based drug development.
• Biochemical Research: Serves as a model compound for studying diketopiperazine chemistry, peptide stability, and intramolecular interactions.
• Precursor for Drug Discovery: Acts as a core structural motif or building block in medicinal chemistry for creating novel therapeutic agents.
• Peptide Impurity Profiling: Essential for characterizing and controlling degradation products in the quality control of synthetic peptide APIs.
• Academic & Industrial R&D: Utilized in life science research exploring bioactive natural products and peptide-derived molecules.

Basic Information

Product Name	Cyclo(-His-Phe)
CAS No.	56586-95-9
Molecular Formula	C15H16N4O2
Molecular Weight	284.32 g/mol
Synonyms	Cyclo(histidylphenylalanine); Cyclo(L-His-L-Phe); L-Histidyl-L-phenylalanine anhydride; 3-Benzyl-6-(1H-imidazol-5-ylmethyl)piperazine-2,5-dione; Histidine-phenylalanine diketopiperazine; c(HF); DKP-His-Phe; HF Cyclic Dipeptide
EINECS	Contact for details

Quality Control

Our Cyclo(-His-Phe) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with the standards expected for research and development-grade fine chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a low-humidity environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.