Description

2-(4-Chloro-Phenyl)-4-Hydroxy-Pyrimidine-5-Carboxylic Acid Ethyl Ester is a high-purity pyrimidine derivative, a crucial advanced pharmaceutical intermediate (API) for synthesizing complex active ingredients. Its core value lies in providing a reliable, structurally defined building block for research and production, ensuring batch-to-batch consistency and accelerating development timelines. This compound is essential for pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel therapeutics, particularly in antiviral and oncology drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer agents.
• Organic Synthesis Building Block: Used in medicinal chemistry for constructing complex pyrimidine-based molecular scaffolds during lead optimization and structure-activity relationship (SAR) studies.
• Research & Development (R&D): Serves as a critical reagent in academic and industrial laboratories for exploring new chemical entities and biological pathways.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals requiring high-purity, functionalized heterocyclic compounds.
• Agrochemical Intermediate: Potential use in the synthesis of advanced crop protection agents and herbicides that utilize chlorophenyl-pyrimidine chemistry.

Basic Information

Product Name	2-(4-Chloro-Phenyl)-4-Hydroxy-Pyrimidine-5-Carboxylic Acid Ethyl Ester
CAS No.	56406-33-8
Molecular Formula	C13H11ClN2O3
Molecular Weight	278.69 g/mol
Synonyms	Ethyl 2-(4-chlorophenyl)-4-hydroxy-5-pyrimidinecarboxylate; 2-(p-Chlorophenyl)-4-hydroxy-5-pyrimidinecarboxylic acid ethyl ester; 4-Hydroxy-2-(4-chlorophenyl)-5-pyrimidinecarboxylic acid ethyl ester; 5-Ethoxycarbonyl-2-(4-chlorophenyl)-4-hydroxypyrimidine; 56406-33-8; 2-(4-Chlorophenyl)-4-hydroxypyrimidine-5-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 2-(4-Chloro-Phenyl)-4-Hydroxy-Pyrimidine-5-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.