Description

H-Thr-Thr-Thr-Oh is a synthetic tripeptide composed of three consecutive L-threonine residues with a free C-terminus. This compound serves as a crucial building block and model substrate in advanced biochemical research and pharmaceutical development. It is primarily utilized by research institutions and manufacturers in the fields of peptide synthesis, proteomics, and drug discovery for studying enzyme kinetics, protein folding, and as a precursor for more complex peptide structures.

Application

• Peptide Synthesis Building Block: Used as a key intermediate in the solid-phase or solution-phase synthesis of longer, biologically active peptides and proteins.
• Biochemical Research: Serves as a standard or model substrate for studying the activity, specificity, and inhibition of proteases, kinases, and other enzymes that recognize threonine motifs.
• Pharmaceutical Development: Employed in the research and development of novel therapeutic peptides, vaccines, and diagnostic agents.
• Proteomics & Structural Biology: Utilized in studies investigating protein-protein interactions, post-translational modifications like phosphorylation (often at threonine sites), and conformational analysis.
• Nutraceutical & Cosmetic Peptide Research: Investigated for potential applications in bioactive peptides for health supplements or cosmetic active ingredients targeting skin and tissue.

Basic Information

Product Name	H-Thr-Thr-Thr-Oh
CAS No.	56395-09-6
Molecular Formula	C12H23N3O8
Molecular Weight	337.33 g/mol
Synonyms	L-Threonyl-L-threonyl-L-threonine; Thr-Thr-Thr; TTT; H-L-Thr-L-Thr-L-Thr-OH; Tri-L-threonine; (2S,2'S,2''S)-2,2',2''-((((Carboxyformimidoyl)azanetriyl)tris(ethane-2,1-diyl))tris(oxy))tris(3-hydroxypropanoic acid); L-Threonine homotripeptide; Threonine tripeptide
EINECS	Contact for details

Quality Control

Our H-Thr-Thr-Thr-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS and NMR for structural confirmation, and chiral purity analysis to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent product degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.