Description

Histidine Hydrochloride is the hydrochloride salt form of the essential amino acid L-Histidine, a critical building block for proteins and enzymes. This high-purity compound is vital for applications requiring precise biochemical activity and stability, such as cell culture media and pharmaceutical formulations. It serves as a key ingredient for manufacturers in the biopharmaceutical, nutraceutical, and research sectors who demand reliable, high-quality raw materials for sensitive processes.

Application

• Pharmaceutical Intermediates: Used in the synthesis of active pharmaceutical ingredients (APIs) and peptide drugs.
• Cell Culture & Fermentation Media: An essential nutrient component in media for mammalian and microbial cell growth and protein production.
• Dietary Supplements & Nutraceuticals: Incorporated into amino acid supplements and clinical nutrition products for its physiological roles.
• Biochemical Research: Serves as a standard, reagent, or buffer component in enzymatic studies and metabolic research.
• Diagnostic Reagents: Used in the formulation of certain diagnostic kits and assay buffers.
• Cosmetic & Personal Care: Employed in skincare formulations for its potential skin-conditioning properties.

Basic Information

Product Name	Histidine Hydrochloride
CAS No.	56272-24-3
Molecular Formula	C6H10ClN3O2 • xH2O
Molecular Weight	191.62 (Anhydrous)
Synonyms	L-Histidine Hydrochloride; L-Histidine Monohydrochloride; (2S)-2-Amino-3-(1H-imidazol-5-yl)propanoic acid hydrochloride; Histidine HCl; Histidine Hydrochloride Monohydrate; Histidinium Chloride; H-His-OH•HCl
EINECS	Contact for details

Quality Control

Our Histidine Hydrochloride is manufactured under a strict quality management system. It is typically tested to meet high-purity standards suitable for pharmaceutical and research applications, with specifications aligning with common pharmacopeial monographs. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every batch upon request, ensuring full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent caking and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Specific Rotation	+8.5° to +10.5° (c=1 in water)
pH (5% Solution)	3.0 - 5.0
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.