Description

5,8-Dideazaisofolic Acid is a specialized heterocyclic compound belonging to the class of folate analogs. This high-purity intermediate is critical for research and development in advanced pharmaceutical synthesis, particularly in the design of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antifolate drugs, enzyme inhibitors, and targeted cancer therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antifolate compounds and enzyme inhibitors for therapeutic applications.
• Biochemical Research: Used as a reference standard and a critical reagent in studies involving folate metabolism and enzyme kinetics.
• Oncology Drug Discovery: Serves as a core scaffold in the research and development of targeted cancer therapies, particularly those aiming to disrupt nucleotide synthesis.
• Academic & Contract Research: Employed in university laboratories and CROs (Contract Research Organizations) for fundamental chemical and biological research projects.
• Process Development: Used in scaling up and optimizing synthetic routes for the production of more complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	5,8-Dideazaisofolic Acid
CAS No.	56239-21-5
Molecular Formula	C19H19N5O6
Molecular Weight	413.39 g/mol
Synonyms	5,8-Dideazaisopteroylglutamic Acid; 5,8-Dideaza-5,6,7,8-tetrahydrofolic Acid; Isofolic Acid Derivative; NSC 127755; 2-[[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]amino]pentanedioic Acid; L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-; 5,8-Dideazaaminopterin analog
EINECS	Contact for details

Quality Control

Our 5,8-Dideazaisofolic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable to support our clients' regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.