Description

5-o-(5-Amino-5-Deoxy-β-D-Xylofuranosyl)-4-o-(2,6-Diamino-2,3,4,6-Tetradeoxy-α-D-Erythro-Hexopyranosyl)-N1-[(S)-4-Amino-2-Hydroxybutyryl]-2-Deoxy-D-Streptamine is a structurally complex aminoglycoside derivative, representing a key intermediate or reference standard in advanced pharmaceutical research and development. Its significance lies in its role as a precursor or analog for novel antibiotics, enabling the study of structure-activity relationships and the development of next-generation therapeutics targeting resistant bacterial strains. This high-purity compound is essential for pharmaceutical R&D laboratories, academic research institutions, and contract manufacturing organizations (CMOs) engaged in the synthesis and analysis of specialized antimicrobial agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control, method validation, and regulatory submissions in antibiotic manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical building block in the multi-step synthesis of novel or semi-synthetic aminoglycoside antibiotics.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies to optimize antibacterial efficacy and reduce ototoxicity or nephrotoxicity.
• Biochemical Assay Development: Utilized as a substrate or inhibitor in enzymatic assays to study bacterial ribosome function and mechanisms of antibiotic resistance.
• Academic & Institutional Research: Supports fundamental research in microbiology, pharmacology, and organic chemistry focused on combating multidrug-resistant pathogens.
• Process Development & Scale-up: Acts as a benchmark for developing and optimizing robust, scalable synthetic routes for GMP production.

Basic Information

Item	Details
Product Name	5-o-(5-Amino-5-Deoxy-β-D-Xylofuranosyl)-4-o-(2,6-Diamino-2,3,4,6-Tetradeoxy-α-D-Erythro-Hexopyranosyl)-N1-[(S)-4-Amino-2-Hydroxybutyryl]-2-Deoxy-D-Streptamine
CAS No.	56182-07-1
Molecular Formula	C23H45N7O11
Molecular Weight	595.65 g/mol
Synonyms	Butirosin B; Ambutyrosin B; 5-O-(5-Amino-5-deoxy-β-D-xylofuranosyl)-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)-N1-[(S)-4-amino-2-hydroxybutyryl]-2-deoxy-D-streptamine; 2-Deoxy-4-O-(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)-5-O-(5-amino-5-deoxy-β-D-xylofuranosyl)-N1-[(S)-4-amino-2-hydroxy-1-oxobutyl]-D-streptamine; Antibiotic Bu 1975 B; Butirosin B component.
EINECS	Contact for details

Quality Control

Every batch of our 5-o-(5-Amino-5-Deoxy-β-D-Xylofuranosyl)-4-o-(2,6-Diamino-2,3,4,6-Tetradeoxy-α-D-Erythro-Hexopyranosyl)-N1-[(S)-4-Amino-2-Hydroxybutyryl]-2-Deoxy-D-Streptamine is manufactured and analyzed under a strict quality management system. We provide comprehensive analytical data to support its use in regulated environments, including full compliance with ICH guidelines for stability and impurity profiling. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting identity, purity, and related substances by validated methods such as HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or under refrigeration (2-8°C) as specified on the label. Due to its hygroscopic nature, the container must be kept in a dry environment. For long-term storage, consider desiccant use and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay (Anhydrous Basis)	97.0% - 102.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.