Description

4-Chloro-5-Bromopyrimidine is a high-value halogenated pyrimidine building block essential for advanced organic synthesis. This heterocyclic compound is prized for its dual reactive sites, enabling selective functionalization to create complex molecular architectures. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and anticancer compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, leveraging its pyrimidine core for biological activity.
• Material Science Research: Serves as a building block for creating organic electronic materials, ligands for metal-organic frameworks (MOFs), and specialty polymers.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and tagged compounds for biological studies.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the presence of both chlorine and bromine substituents.
• Nucleoside & Nucleotide Chemistry: Fundamental starting material for the preparation of modified nucleosides and nucleotides for therapeutic and diagnostic applications.

Basic Information

Product Name	4-Chloro-5-Bromopyrimidine
CAS No.	56181-39-6
Molecular Formula	C4H2BrClN2
Molecular Weight	193.43 g/mol
Synonyms	5-Bromo-4-chloropyrimidine; 4-Chloro-5-bromo-pyrimidine; Pyrimidine, 4-chloro-5-bromo-; 5-Bromo-4-chloro-1,3-diazine; 1,3-Diazine, 5-bromo-4-chloro-; 4-Chloro-5-bromo-1,3-diazine; 4-Chloro-5-brom-1,3-diazin (German); 4-クロロ-5-ブロモピリミジン (Japanese)
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Bromopyrimidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each lot, supporting cGMP and ISO standards for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.