Description

Alamethicin F, Alamethicin Rf 50, Atroviridin A, 18-L-Glutamine-Alamethicin I is a peptide antibiotic belonging to the peptaibol family, characterized by its unique incorporation of the amino acid glutamine. This compound is valued for its potent membrane-disrupting properties, making it a critical tool in biophysical research and a model for studying ion channel formation. It is primarily utilized by researchers and developers in the life sciences sector for investigating membrane permeability, antimicrobial mechanisms, and as a standard in analytical chemistry. The product is supplied under the CAS registry number 56165-93-6.

Application

• Biophysical Research: As a model ion channel-forming peptide to study membrane permeability, pore formation, and electrical properties of lipid bilayers.
• Antimicrobial Studies: Investigation of its mechanism of action against bacteria and fungi, serving as a reference compound for novel antibiotic development.
• Cell Biology: Used to permeabilize cell membranes in controlled experiments to introduce molecules or study intracellular processes.
• Analytical Standard: Serves as a high-purity reference standard for HPLC, LC-MS, and other chromatographic or spectroscopic methods in quality control laboratories.
• Pharmaceutical Research: Exploration of its potential and structure-activity relationships (SAR) for designing new therapeutic agents.

Basic Information

Item	Details
Product Name	Alamethicin F, Alamethicin Rf 50, Atroviridin A, 18-L-Glutamine-Alamethicin I
CAS No.	56165-93-6
Molecular Formula	C92H150N22O25
Molecular Weight	1964.3 g/mol (approx.)
Synonyms	Alamethicin F; Alamethicin Rf 50; Atroviridin A; 18-L-Glutamine-Alamethicin I; Peptaibol antibiotic; Alamethicin I, 18-L-Gln-; Antibiotic U-22324; Sequence: Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phol
EINECS	Contact for details

Quality Control

Our Alamethicin F is produced and tested under stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is analyzed using advanced techniques including HPLC and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, ethanol, methanol; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.