Description

2,4-Bis[(Trimethylsilyl)Oxy]-5-(Ethoxymethyl)Pyrimidine CAS NO 56145-29-0 is a high-value, organosilicon-protected pyrimidine derivative. This compound serves as a critical protected intermediate in the synthesis of complex nucleoside analogs and active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers for the development of antiviral and anticancer therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of modified nucleosides and nucleotides.
• Antiviral Drug Development: Used in research and production of antiviral agents targeting viral polymerases.
• Anticancer Agent Synthesis: Intermediate for creating novel pyrimidine-based chemotherapeutic compounds.
• Organic Synthesis Reagent: Serves as a protected synthon in multi-step organic synthesis, leveraging its silyl ether groups for selective reactivity.
• Biochemical Research: Utilized in academic and industrial research to study enzyme inhibition and nucleic acid chemistry.
• Process Chemistry: Employed in scale-up and process optimization for the manufacture of high-value fine chemicals.

Basic Information

Product Name	2,4-Bis[(Trimethylsilyl)Oxy]-5-(Ethoxymethyl)Pyrimidine
CAS No.	56145-29-0
Molecular Formula	C14H28N2O3Si2
Molecular Weight	328.55 g/mol
Synonyms	5-(Ethoxymethyl)-2,4-bis(trimethylsilyloxy)pyrimidine; 2,4-Bis(trimethylsiloxy)-5-ethoxymethylpyrimidine; 5-Ethoxymethyl-2,4-bis(trimethylsilyloxy)pyrimidine; Pyrimidine, 2,4-bis[(trimethylsilyl)oxy]-5-(ethoxymethyl)-; 56145-29-0; 2,4-Bis-O-(trimethylsilyl)-5-ethoxymethyluracil (related precursor); TMS-protected 5-ethoxymethyluracil derivative
EINECS	Contact for details

Quality Control

Our 2,4-Bis[(Trimethylsilyl)Oxy]-5-(Ethoxymethyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment to guarantee supply consistency and traceability, supporting your cGMP and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.