Description

Nourseothricin is a broad-spectrum aminoglycoside antibiotic complex, primarily composed of streptothricin F and D. This compound is valued for its potent activity against a wide range of Gram-positive and Gram-negative bacteria, including mycobacteria. It serves as a critical selective agent in molecular biology and biotechnology, particularly for the selection of genetically modified cells. Industries such as pharmaceutical research, life sciences, and industrial microbiology utilize this antibiotic for its reliable efficacy and stability.

Application

• Molecular Biology & Genetic Engineering: Used as a selective agent in cell culture media for the stable maintenance of plasmids containing the nourseothricin resistance (NatR) gene.
• Microbiological Research: Employed in studies of bacterial resistance mechanisms and for the isolation of specific microbial strains.
• Pharmaceutical Development: Serves as a reference standard and as an active pharmaceutical ingredient (API) in antibiotic research and formulation studies.
• Agricultural Biotechnology: Applied in the development of transgenic plants and crops with engineered resistance traits.
• Industrial Fermentation: Acts as an additive in fermentation processes to prevent bacterial contamination.
• Veterinary Medicine: Investigated for use in topical or oral formulations to treat bacterial infections in animals.

Basic Information

Product Name	Nourseothricin
CAS No.	56089-12-4
Molecular Formula	C31H58N8O13 • H2SO4 (Sulfate salt)
Molecular Weight	Approx. 765.8 g/mol (Free base)
Synonyms	Streptothricin; Antibiotic S-15; Antibiotic SF-701; Antibiotic 136; Nourseothricin Sulfate; Streptothricin F & D complex; Natamycin (Note: Not to be confused with the polyene macrolide); NatR Antibiotic
EINECS	Contact for details

Quality Control

Our Nourseothricin is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, potency, and consistency. Specifications are aligned with research-grade standards, and comprehensive Certificates of Analysis (COA) detailing assay, purity, and microbiological potency are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Potency (Microbiological)	≥ 800 µg/mg
Water Content (KF)	≤ 5.0%
pH (1% Solution)	4.0 - 6.0
Residue on Ignition	≤ 1.0%
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.