Description

4-Chloro-2-Ethoxy-5-Fluoropyrimidine is a high-purity fluorinated pyrimidine derivative, a crucial building block in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents, makes it an indispensable intermediate for creating complex molecules with targeted biological activity. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of nucleoside analogs, antiviral agents, and other active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging its halogenated pyrimidine core.
• Chemical Synthesis: Serves as a versatile precursor in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce the pyrimidine moiety into more complex structures.
• Material Science: Potential building block for the creation of specialty polymers, liquid crystals, or organic electronic materials.
• Contract Research & Development (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	4-Chloro-2-Ethoxy-5-Fluoropyrimidine
CAS No.	56076-20-1
Molecular Formula	C6H6ClFN2O
Molecular Weight	176.58 g/mol
Synonyms	5-Fluoro-2-ethoxy-4-chloropyrimidine; 4-Chloro-5-fluoro-2-ethoxypyrimidine; 2-Ethoxy-4-chloro-5-fluoropyrimidine; 56076-20-1; Pyrimidine, 4-chloro-2-ethoxy-5-fluoro-; 4-Chloro-5-fluoro-2-ethoxypyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Ethoxy-5-Fluoropyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.