Description

11α-(Acetyloxy)-3β-[[6-Methyl-4,5-(Methylenebisoxy)Tetrahydro-3-Oxo-2H-Pyran-2-Yl]Oxy]-5,14-Dihydroxy-12-Oxo-5α-Card-20(22)-Enolide is a high-purity, structurally complex cardenolide derivative, a class of compounds known for their potent biological activity. This compound is of significant interest for advanced pharmaceutical research and development, particularly in the study of cardiac glycosides and their mechanisms. It serves as a critical reference standard and a valuable pharmaceutical intermediate for researchers and manufacturers in the life sciences sector. Target users include R&D laboratories, academic institutions, and pharmaceutical companies engaged in cardiovascular drug discovery and synthesis.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in HPLC, LC-MS, and other chromatographic systems.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic building block in the production of novel cardiac glycoside-based therapeutics.
• Biochemical Research: Employed in pharmacological studies to investigate sodium-potassium ATPase inhibition, cardiac contractility, and cell signaling pathways.
• Academic Research: Utilized in universities and research institutes for structural-activity relationship (SAR) studies and medicinal chemistry projects.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.

Basic Information

Product Name	11α-(Acetyloxy)-3β-[[6-Methyl-4,5-(Methylenebisoxy)Tetrahydro-3-Oxo-2H-Pyran-2-Yl]Oxy]-5,14-Dihydroxy-12-Oxo-5α-Card-20(22)-Enolide
CAS No.	56051-65-1
Molecular Formula	C30H38O12
Molecular Weight	590.62 g/mol
Synonyms	3β-[(6-Methyl-4,5-methylenedioxy-3-oxo-2-tetrahydropyranyl)oxy]-11α-acetoxy-5,14-dihydroxy-12-oxo-5α-card-20(22)-enolide; 11α-Acetoxy-3β-[(6-methyl-4,5-methylenedioxy-3-oxo-2-tetrahydropyranyl)oxy]-5,14-dihydroxy-12-oxo-5α-card-20(22)-enolide; Cardenolide derivative 56051-65-1; 5α-Card-20(22)-enolide, 11α-(acetyloxy)-3β-[[6-methyl-4,5-(methylenebisoxy)tetrahydro-3-oxo-2H-pyran-2-yl]oxy]-5,14-dihydroxy-12-oxo-
EINECS	Contact for details

Quality Control

Our 11α-(Acetyloxy)-3β-[[6-Methyl-4,5-(Methylenebisoxy)Tetrahydro-3-Oxo-2H-Pyran-2-Yl]Oxy]-5,14-Dihydroxy-12-Oxo-5α-Card-20(22)-Enolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production requirements. Our commitment to cGMP principles guarantees consistent quality and supply reliability for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. The product is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.