Description

Boc-D-Lys(Z)-Oh CAS NO 55878-47-2 is a protected derivative of the D-isomer of the amino acid lysine, featuring both Boc (tert-butoxycarbonyl) and Z (benzyloxycarbonyl) protecting groups. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of D-lysine residues into peptide chains, enabling the creation of stable, non-natural peptide structures.
• Pharmaceutical Research & Development: Serves as a crucial precursor in the synthesis of peptide-based drug candidates, including enzyme inhibitors, receptor agonists/antagonists, and antimicrobial peptides.
• Bioconjugation and Probe Development: Used to introduce functionalized lysine side chains into biomolecules for labeling, imaging, or creating antibody-drug conjugates (ADCs).
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic Research: Essential for studies in peptide chemistry, structural biology, and understanding the role of D-amino acids in biological systems.
• Process Development: Used in scaling up synthetic routes for peptide APIs (Active Pharmaceutical Ingredients) under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	Boc-D-Lys(Z)-Oh
CAS No.	55878-47-2
Molecular Formula	C₁₉H₂₈N₂O₆
Molecular Weight	380.44 g/mol
Synonyms	N2-[(Benzyloxy)carbonyl]-N6-[(1,1-dimethylethoxy)carbonyl]-D-lysine; Nα-Boc-Nε-Z-D-Lysine; D-Lysine, N2-[(benzyloxy)carbonyl]-N6-[(1,1-dimethylethoxy)carbonyl]-; Boc-D-Lys(Z)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)hexanoic acid (related Fmoc variant); N-α-Boc-N-ε-Cbz-D-lysine; Boc-D-Lys(Cbz)-OH; tert-Butyl N-[(2R)-6-{[(benzyloxy)carbonyl]amino}-1-hydroxy-1-oxohexan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our Boc-D-Lys(Z)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, optical rotation, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.