Description

Lomotil is a pharmaceutical active ingredient, specifically a combination of diphenoxylate hydrochloride and atropine sulfate, primarily used for its antidiarrheal properties. Its value lies in its ability to effectively manage acute and chronic diarrhea by slowing intestinal motility, making it a critical component in therapeutic formulations. This compound is essential for pharmaceutical manufacturers and research institutions developing gastrointestinal medications, requiring a reliable supply of high-purity active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical API: Primary active ingredient in prescription antidiarrheal medications.
• Gastrointestinal Therapeutics: Formulated into tablets, liquids, or other dosage forms for the symptomatic treatment of diarrhea.
• Clinical Research: Used in studies investigating gastrointestinal motility disorders and the efficacy of antidiarrheal agents.
• Veterinary Medicine: Potential application in managing diarrhea in certain animal species under veterinary guidance.
• Reference Standard: Serves as a chemical reference standard for quality control and analytical method development in pharmaceutical labs.

Basic Information

Product Name	Lomotil
CAS No.	55840-97-6
Molecular Formula	C₃₀H₃₂N₂O₂ • C₁₇H₂₃NO₃ • HCl • ½H₂SO₄ • 2½H₂O
Molecular Weight	Contact for details
Synonyms	Diphenoxylate HCl and Atropine Sulfate; Diphenoxylate Hydrochloride with Atropine Sulfate; Loperamide analogue (structural); Antidiarrheal Agent; 1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic Acid Ethyl Ester Hydrochloride with Atropine Sulfate; R-1132; NSC-527986
EINECS	Contact for details

Quality Control

Our Lomotil is manufactured and tested to meet stringent pharmaceutical standards. Quality assurance protocols are designed to ensure batch-to-batch consistency, high purity, and compliance with relevant pharmacopeial monographs where applicable. A comprehensive Certificate of Analysis (COA) detailing identity, assay, impurity profile, and other critical parameters is provided with each shipment to support your quality systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, protect from moisture. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White or almost white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (Diphenoxylate HCl)	98.0% - 102.0%
Assay (Atropine Sulfate)	Meets requirement
Related Substances (HPLC)	NMT 1.0% total impurities
Water Content (KF)	NMT 5.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.