Description

5'-Trifluoroacetamido-5'-Deoxythymidine is a high-purity nucleoside derivative, a key synthetic intermediate in advanced pharmaceutical research and development. Its primary value lies in its role as a crucial building block for the synthesis of modified oligonucleotides and nucleotide analogs, enabling the development of novel therapeutic agents. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors, particularly those focused on antiviral drug discovery, oncology research, and the development of molecular probes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Oligonucleotide Synthesis: Used as a modified nucleoside phosphoramidite building block for creating labeled or functionalized DNA/RNA strands.
• Biochemical Research: Serves as a tool compound in enzymatic studies and for investigating nucleoside metabolism pathways.
• Pro-drug Development: Utilized in the design and synthesis of nucleoside pro-drugs to enhance bioavailability and targeting.
• Molecular Probe Fabrication: Acts as a component for creating diagnostic probes and tools for genetic analysis.
• Academic & Contract Research: Employed in university and CRO laboratories for fundamental research in medicinal chemistry.

Basic Information

Product Name	5'-Trifluoroacetamido-5'-Deoxythymidine
CAS No.	55812-00-5
Molecular Formula	C12H14F3N3O6
Molecular Weight	353.25 g/mol
Synonyms	5'-Deoxy-5'-(trifluoroacetamido)thymidine; 5'-Trifluoroacetamidothymidine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-2,4-dioxopyrimidin-1-ium-3-olate 5'-(2,2,2-trifluoroacetamide); 5'-Amino-5'-deoxythymidine Trifluoroacetamide; TFA-dT; 5'-Trifluoroacetylamino-5'-deoxythymidine
EINECS	Contact for details

Quality Control

Our 5'-Trifluoroacetamido-5'-Deoxythymidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability, consistency, and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.