Description

6-Hydroxyphenprocoumon is a key hydroxylated derivative of the anticoagulant phenprocoumon, serving as a critical intermediate and reference standard in pharmaceutical research and development. Its primary value lies in enabling the study of metabolic pathways, pharmacokinetics, and the synthesis of related bioactive compounds. This high-purity chemical is essential for researchers and manufacturers in the pharmaceutical, analytical, and fine chemical sectors who require reliable building blocks for anticoagulant drug development and quality control.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis and research of anticoagulant medications and their analogs.
• Metabolite Reference Standard: Used as an analytical standard in HPLC, LC-MS, and other chromatographic methods to identify and quantify the 6-hydroxy metabolite of phenprocoumon in biological matrices.
• Biochemical Research: Employed in studies investigating cytochrome P450 enzyme activity, drug metabolism, and structure-activity relationships (SAR) of vitamin K antagonists.
• Fine Chemical Synthesis: Serves as a specialized starting material or intermediate for the preparation of novel coumarin-based compounds with potential therapeutic applications.
• Quality Control & Assurance: Utilized by pharmaceutical QC laboratories to develop and validate methods for impurity profiling and assay of phenprocoumon-based drug substances and products.

Basic Information

Product Name	6-Hydroxyphenprocoumon
CAS No.	55789-05-4
Molecular Formula	C₁₈H₁₆O₅
Molecular Weight	312.32 g/mol
Synonyms	6-Hydroxy-3-(1-phenylpropyl)-4-hydroxycoumarin; 4-Hydroxy-3-[1-(phenyl)propyl]-2H-1-benzopyran-2-one, 6-hydroxy-; Phenprocoumon, 6-hydroxy-; 6-Hydroxy-3-(α-ethylbenzyl)-4-hydroxycoumarin; 6-OH-Phenprocoumon
EINECS	Contact for details

Quality Control

Our 6-Hydroxyphenprocoumon is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR), to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.