Description

Gentamicin A3 is a key aminoglycoside antibiotic component, essential for its potent bactericidal activity against a wide spectrum of Gram-negative and some Gram-positive bacteria. Its primary value lies in its critical role as a reference standard and active pharmaceutical ingredient (API) for quality control and research in antibiotic development. This compound is vital for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on antimicrobial agents, antibiotic resistance studies, and the production of high-purity medicinal formulations.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of gentamicin sulfate complex in pharmacopeial testing (USP, EP).
• Active Pharmaceutical Ingredient (API): Serves as a critical component in the formulation of injectable antibiotic preparations for serious systemic infections.
• Microbiological Research: Employed in studies investigating mechanisms of aminoglycoside action, bacterial resistance pathways, and synergistic drug combinations.
• Quality Control & Assurance: Essential for in-house HPLC, LC-MS, or microbiological assay calibration within pharmaceutical quality control laboratories.
• Veterinary Medicine: Used in the development and quality testing of antimicrobial treatments for animals.
• Biochemical Research: Applied in studies of protein synthesis inhibition and ribosomal function.

Basic Information

Product Name	Gentamicin A3
CAS No.	55715-67-8
Molecular Formula	C20H41N5O7
Molecular Weight	463.57 g/mol
Synonyms	Gentamicin C1a; Gentamycin A3; Gentamicin A3 (C1a); O-2-Amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-3-(methylamino)-α-L-arabinopyranosyl-(1→6)]-2-deoxy-D-streptamine; Antibiotic G 418 Component A3; Sch 14342; Garamycin Component A3; NSC 329680
EINECS	Contact for details

Quality Control

Our Gentamicin A3 is produced and tested under strict quality management systems. Each batch is analyzed to meet high-purity standards suitable for pharmaceutical research and development. Comprehensive testing includes identification, assay, and related substance analysis via validated methods such as HPLC. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.