Description

4-[(2,4-Diaminopyrimidine-5-Yl)Methyl]-2,6-Dimethoxybenzoic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate with a distinct molecular architecture. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring diaminopyrimidine motifs. It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing novel drug candidates and process optimization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of dihydrofolate reductase (DHFR) inhibitors and other targeted therapeutics.
• Antifolate Drug Research: Serves as a core scaffold for developing new antifolate agents with potential antimicrobial or anticancer activity.
• Chemical Biology & Proteomics: Used in the design and synthesis of chemical probes for studying enzyme function and biological pathways.
• Agrochemical Development: Employed in research for creating novel crop protection agents that leverage the pyrimidine structure.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies and novel compound library generation.
• Process Chemistry & Scale-Up: Acts as a defined starting material for optimizing synthetic routes and scaling production of target molecules.

Basic Information

Product Name	4-[(2,4-Diaminopyrimidine-5-Yl)Methyl]-2,6-Dimethoxybenzoic Acid Ethyl Ester
CAS No.	55687-48-4
Molecular Formula	C₁₇H₂₀N₄O₄
Molecular Weight	344.37 g/mol
Synonyms	Ethyl 4-[(2,4-diaminopyrimidin-5-yl)methyl]-2,6-dimethoxybenzoate; 2,6-Dimethoxy-4-[(2,4-diamino-5-pyrimidinyl)methyl]benzoic Acid Ethyl Ester; 5-[(3,5-Dimethoxy-4-ethoxycarbonylphenyl)methyl]-2,4-pyrimidinediamine; 55687-48-4; Benzoic acid, 4-[(2,4-diamino-5-pyrimidinyl)methyl]-2,6-dimethoxy-, ethyl ester
EINECS	Contact for details

Quality Control

Our production of 4-[(2,4-Diaminopyrimidine-5-Yl)Methyl]-2,6-Dimethoxybenzoic Acid Ethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with cGMP and ISO standards for pharmaceutical intermediates, with specifications tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.